Publications
REVIEWS, COMMENTARIES & BOOK CHAPTERS
- Woodland DL, Kohlmeier JE, Ely KH, Roberts AD, Yager EJ, Blackman MA. “Beneficial and detrimental manifestations of age on CD8+ T cell memory to respiratory pathogens” in: Handbook of Immunosenescence: Basic Understanding and Clinical Applications. Edited by Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G., Springer, (2016 Update - In Press)
- Kohlmeier JE, Ely KH, Roberts AD, Yager EJ, Blackman MA, Woodland DL. “Beneficial and detrimental manifestations of age on CD8+ T cell memory to respiratory pathogens.” in: Handbook on Immunosenescence: Basic Understanding and Clinical Applications. Edited by Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G., Springer, pp. 979-996, (2009).
- Orme, IM and Roberts AD. Unit 19.5 “Animal Models of Mycobacteria Infection” in Current Protocols in Immunology, Edited by Coligan JE [et. al.] Updated Quarterly, Unit 19.5, John Wiley & Sons, Inc. (2008)
- Ely KH, Roberts AD, Kohlmeier JE, Blackman MA, Woodland DL. “Aging and CD8+ T cell immunity to respiratory virus infections.” Exp Gerontol. May;42(5):427-31. Epub 2007 Jan 2. Review. (2007)
- Hikono H, Kohlmeier JE, Ely KH, Scott I, Roberts AD, Blackman MA, Woodland DL. “T-cell memory and recall responses to respiratory virus infections.” Immunol Rev. Jun;211:119-32. Review. (2006)
- Roberts AD, Belisle JT, Turner J, Gonzales-Juarerro, M, Cooper AM, and Orme IM. "Murine models of tuberculosis" in Methods in Microbiology - Immunology of Infection, Edited by Kaufmann SHE and Kabelitz D. Volume 32, 433-462, Academic Press (2002)
- Roberts AD, Belisle JT, Cooper AM, and Orme IM. "Murine models of tuberculosis" in Methods in Microbiology - Immunology of Infection, Edited by Kaufmann SHE and Kabelitz D. Volume 25, 389-417, Academic Press (1998)
PEER REVIEWED PUBLICATIONS
- Freeman ML, Burkum CE, Cookenham T, Roberts AD, Lanzer KG, Huston GE, Jensen MK, Sidney J, Peters B, Kohlmeier JE, Woodland DL, van Dyk LF, Sette A, Blackman MA. (2014) CD4 T Cells Specific for a Latency-Associated g-Herpesvirus Epitope Are Polyfunctional and Cytotoxic. J Immunol. 2014 Nov 5. pii: 1302060. [Epub ahead of print] PubMed PMID: 25378595.
- Freeman ML, Roberts AD, Burkum CE, Woodland DL, Blackman MA. (2014) Promotion of asubdominant CD8 T cell response during murinegammaherpesvirus 68 infection in the absence of CD4 T cell help. J Virol. 2014 Jul;88(14):7862-9.
- Brincks EL, Roberts AD, Cookenham T, Sell S, Kohlmeier JE, Blackman MA, Woodland DL. (2013) Antigen-specific memory regulatory CD4+Foxp3+ T cells control memory responses to influenza virus infection. J Immunol. Apr 1;190(7):3438-46.
- Freeman ML, Burkum CE, Lanzer KG, Roberts AD, Pinkevych M, Itakura A, Kummer LW, Szaba FM, Davenport MP, McCarty OJ, Woodland DL, Smiley ST, Blackman MA. (2013) Gammaherpesvirus latency induces antibody-associated thrombocytopenia in mice. J Autoimmun. May;42:71-9.
- Connor LM, Kohlmeier JE, Ryan L, Roberts AD, Cookenham T, Blackman MA, Woodland DL. (2012) Early dysregulation of the memory CD8+ T cell repertoire leads to compromised immune responses to secondary viral infection in the aged. Immun Ageing. Dec 18;9(1):28.
- Kohlmeier JE, Reiley WW, Perona-Wright G, Freeman ML, Yager EJ, Connor LM, Brincks EL, Cookenham T, Roberts AD, Burkum CE, Sell S, Winslow GM, Blackman MA, Mohrs M, Woodland DL (2011) Inflammatory chemokine receptors regulate CD8+ T cell contraction and memory generation following infection. J Exp Med. Aug 1;208(8):1621-34.
- Kohlmeier JE, Connor LM, Roberts AD, Cookenham T, Martin K, Woodland DL. (2010) Nonmalignant clonal expansions of memory CD8+ T cells that arise with age vary in their capacity to mount recall responses to infection. J Immunol. Sep 15;185(6):3456-62.
- Kohlmeier JE, Cookenham T, Roberts AD, Miller SC, Woodland DL. (2010) Type I interferons regulate cytolytic activity of memory CD8(+) T cells in the lung airways during respiratory virus challenge. Immunity. Jul 23;33(1):96-105.
- Takamura S, Roberts AD, Jelley-Gibbs DM, Wittmer ST, Kohlmeier JE, Woodland DL. (2010) The route of priming influences the ability of respiratory virus-specific memory CD8+ T cells to be activated by residual antigen. J Exp Med. Jun 7;207(6):1153-60.
- Kohlmeier JE, Cookenham T, Miller SC, Roberts AD, Christensen JP, Thomsen AR, Woodland DL. (2009) CXCR3 directs antigen-specific effector CD4+ T cell migration to the lung during parainfluenza virus infection. J Immunol. Oct 1;183(7):4378-84.
- Reiley WW, Calayag MD, Wittmer ST, Huntington JL, Pearl JE, Fountain JJ, Martino CA, Roberts AD, Cooper AM, Winslow GM, Woodland DL. (2008) ESAT-6-specific CD4 T cell responses to aerosol Mycobacterium tuberculosis infection are initiated in the mediastinal lymph nodes. Proc Natl Acad Sci U S A. Aug 5;105(31):10961-6.
- Kohlmeier JE, Miller SC, Smith J, Lu B, Gerard C, Cookenham T, Roberts AD, Woodland DL. (2008) The chemokine receptor CCR5 plays a key role in the early memory CD8+ T cell response to respiratory virus infections. Immunity. Jul 18;29(1):101-13.
- Ely KH, Ahmed M, Kohlmeier JE, Roberts AD, Wittmer ST, Blackman MA, Woodland DL. (2007) Antigen-specific CD8+ T cell clonal expansions develop from memory T cell pools established by acute respiratory virus infections. J Immunol. Sep 15;179(6):3535-42.
- Hikono H, Kohlmeier JE, Takamura S, Wittmer ST, Roberts AD, Woodland DL. (2007) Activation phenotype, rather than central- or effector-memory phenotype, predicts the recall efficacy of memory CD8+ T cells. J Exp Med. Jul 9;204(7):1625-36.
- Powell TJ, Strutt T, Reome J, Hollenbaugh JA, Roberts AD, Woodland DL, Swain SL, Dutton RW. (2007) Priming with cold-adapted influenza A does not prevent infection but elicits long-lived protection against supralethal challenge with heterosubtypic virus. J Immunol. Jan 15;178(2):1030-8.
- Lawrence BP, Roberts AD, Neumiller JJ, Cundiff JA, Woodland DL. (2006) Aryl hydrocarbon receptor activation impairs the priming but not the recall of influenza virus-specific CD8+ T cells in the lung. J Immunol. Nov 1;177(9):5819-28.
March 2008 - Best Immunotoxicology Manuscript of the Year from the Society of Toxicology. - Ely KH, Cookenham T, Roberts AD, Woodland DL. (2006) Memory T cell populations in the lung airways are maintained by continual recruitment. J Immunol. Jan 1;176(1):537-43.
- Goodrich SP, Muller-Steffner H, Osman A, Moutin MJ, Kusser K, Roberts A, Woodland DL, Randall TD, Kellenberger E, LoVerde PT, Schuber F, Lund FE. (2005) Production of calcium-mobilizing metabolites by a novel member of the ADP-ribosyl cyclase family expressed in Schistosoma mansoni. Biochemistry. Aug 23;44(33):11082-97.
- Roberts AD, Ely KH, Woodland DL. (2005) Differential contributions of central and effector memory T cells to recall responses. J Exp Med. Jul 4;202(1):123-33. Epub 2005 Jun 27.
- Roberts AD, Woodland DL. (2004) Cutting edge: Effector memory CD8+ T cells play a prominent role in recall responses to secondary viral infection in the lung. J Immunol. Jun 1;172(11):6533-7.
- Ely KH, Roberts AD, Woodland DL. (2003) Cutting edge: Effector memory CD8+ T cells in the lung airways retain the potential to mediate recall responses. J Immunol. Oct 1;171(7):3338-42.
- Crowe SR, Turner SJ, Miller SC, Roberts AD, Rappolo RA, Doherty PC, Ely KH, Woodland DL. (2003) Differential antigen presentation regulates the changing patterns of CD8+ T cell immunodominance in primary and secondary influenza virus infections. J Exp Med. Aug 4;198(3):399-410.
- Ely, K.H., Cauley, L.S., Roberts, A.D., Brennan, J.W., Cookenham, T., and Woodland, D.L. (2003) Non-specific recruitment of memory CD8+ T cells to the lung airways during respiratory virus infections. J. Immunol., Feb 1;170(3):1423-9.
- Winslow, G.M., Roberts, A.D., Blackman, M.A., and Woodland D.L. (2003) Persistence and turnover of antigen-specific CD4 T cells during chronic tuberculosis infection. J. Immunol., Feb 15;170(4):2046-52.
- Hogan R.J., Cauley L.S., Ely K.H., Cookenham T., Roberts A.D., Brennan J.W., Monard S. & Woodland D.L. (2002) Long-term maintenance of virus-specific effector memory CD8+ T cells in the lung airways depends on proliferation. J Immunol, 169, 4976-81.
- Hogan R.J., Zhong W., Usherwood E.J., Cookenham T., Roberts A.D. & Woodland D.L. (2001) Protection from respiratory virus infections can be mediated by antigen- specific CD4(+) T cells that persist in the lungs. J Exp Med, 193, 981-6.
- Hogan R.J., Usherwood E.J., Zhong W., Roberts A.A., Dutton R.W., Harmsen A.G. & Woodland D.L. (2001) Activated antigen-specific CD8+ T cells persist in the lungs following recovery from respiratory virus infections. J Immunol, 166, 1813-22.
- Zhong W., Roberts A.D. & Woodland D.L. (2001) Antibody-independent antiviral function of memory CD4+ T cells in vivo requires regulatory signals from CD8+ effector T cells. J Immunol, 167, 1379-86.
- Turner O.C., Roberts A.D., Frank A.A., Phalen S.W., McMurray D.M., Content J., Denis O., D'Souza S., Tanghe A., Huygen K. & Orme I.M. (2000) Lack of protection in mice and necrotizing bronchointerstitial pneumonia with bronchiolitis in guinea pigs immunized with vaccines directed against the hsp60 molecule of Mycobacterium tuberculosis. Infect Immun, 68, 3674-9.
- Dow S.W., Roberts A., Vyas J., Rodgers J., Rich R.R., Orme I. & Potter T.A. (2000) Immunization with f-Met peptides induces immune reactivity against Mycobacterium tuberculosis. Tuber Lung Dis, 80, 5-13.
- Dillon D.C., Alderson M.R., Day C.H., Lewinsohn D.M., Coler R., Bement T., Campos-Neto A., Skeiky Y.A., Orme I.M., Roberts A., Steen S., Dalemans W., Badaro R. & Reed S.G. (1999) Molecular characterization and human T-cell responses to a member of a novel Mycobacterium tuberculosis mtb39 gene family. Infect Immun, 67, 2941-50.
- Moran A.J., Doran J.L., Wu J., Treit J.D., Ekpo P., Kerr V.J., Roberts A.D., Orme I.M., Galant S., Ress S.R. & Nano F.E. (1999) Identification of novel immunogenic Mycobacterium tuberculosis peptides that stimulate mononuclear cells from immune donors. FEMS Microbiol Lett, 177, 123-30.
- Orme I.M. & Roberts A.D. (1998) Changes in integrin/adhesion molecule expression, but not in the T-cell receptor repertoire, in old mice infected with tuberculosis. Mech Ageing Dev, 105, 19-29.
- DiTirro J., Rhoades E.R., Roberts A.D., Burke J.M., Mukasa A., Cooper A.M., Frank A.A., Born W.K. & Orme I.M. (1998) Disruption of the cellular inflammatory response to Listeria monocytogenes infection in mice with disruptions in targeted genes. Infect Immun, 66, 2284-9.
- Roberts A.D. & Orme I.M. (1998) CD95 expression in aged mice infected with tuberculosis. Infect Immun, 66, 5036-40.
- Baldwin S.L., D'Souza C., Roberts A.D., Kelly B.P., Frank A.A., Lui M.A., Ulmer J.B., Huygen K., McMurray D.M. & Orme I.M. (1998) Evaluation of new vaccines in the mouse and guinea pig model of tuberculosis. Infect Immun, 66, 2951-9.
- Cooper A.M., Roberts A.D., Rhoades E.R., Callahan J.E., Getzy D.M. & Orme I.M. (1995) The role of interleukin-12 in acquired immunity to Mycobacterium tuberculosis infection. Immunology, 84, 423-32.
- Cooper A.M., Callahan J.E., Griffin J.P., Roberts A.D. & Orme I.M. (1995) Old mice are able to control low-dose aerogenic infections with Mycobacterium tuberculosis. Infect Immun, 63, 3259-65.
- Roberts A.D., Sonnenberg M.G., Ordway D.J., Furney S.K., Brennan P.J., Belisle J.T. & Orme I.M. (1995) Characteristics of protective immunity engendered by vaccination of mice with purified culture filtrate protein antigens of Mycobacterium tuberculosis. Immunology, 85, 502-8.
- Orme I.M., Roberts A.D., Furney S.K. & Skinner P.S. (1994) Animal and cell-culture models for the study of mycobacterial infections and treatment. Eur J Clin Microbiol Infect Dis, 13, 994-9.
- Orme I.M., Roberts A.D., Griffin J.P. & Abrams J.S. (1993) Cytokine secretion by CD4 T lymphocytes acquired in response to Mycobacterium tuberculosis infection. J Immunol, 151, 518-25.
- Orme I.M., Griffin J.P., Roberts A.D. & Ernst D.N. (1993) Evidence for a defective accumulation of protective T cells in old mice infected with Mycobacterium tuberculosis. Cell Immunol, 147, 222-9.
- Roberts A.D., Ordway D.J. & Orme I.M. (1993) Listeria monocytogenes infection in beta 2 microglobulin-deficient mice. Infect Immun, 61, 1113-6.
- Orme I.M., Furney S.K. & Roberts A.D. (1992) Dissemination of enteric Mycobacterium avium infections in mice rendered immunodeficient by thymectomy and CD4 depletion or by prior infection with murine AIDS retroviruses. Infect Immun, 60, 4747-53.
- Chatterjee D., Roberts A.D., Lowell K., Brennan P.J. & Orme I.M. (1992) Structural basis of capacity of lipoarabinomannan to induce secretion of tumor necrosis factor. Infect Immun, 60, 1249-53.
- Orme I.M., Miller E.S., Roberts A.D., Furney S.K., Griffin J.P., Dobos K.M., Chi D., Rivoire B. & Brennan P.J. (1992) T lymphocytes mediating protection and cellular cytolysis during the course of Mycobacterium tuberculosis infection. Evidence for different kinetics and recognition of a wide spectrum of protein antigens. J Immunol, 148, 189-96.
- Furney S.K., Skinner P.S., Roberts A.D., Appelberg R. & Orme I.M. (1992) Capacity of Mycobacterium avium isolates to grow well or poorly in murine macrophages resides in their ability to induce secretion of tumor necrosis factor. Infect Immun, 60, 4410-3.
- Orme I.M., Lee B.Y., Appelberg R., Miller E.S., Chi D.L., Griffin J.P. & Roberts A.D. (1991) T cell response in acquired protective immunity to Mycobacterium tuberculosis infection. Bull Int Union Tuberc Lung Dis, 66, 7-13.
- Furney S.K., Roberts A.D. & Orme I.M. (1990) Effect of rifabutin on disseminated Mycobacterium avium infections in thymectomized, CD4 T-cell-deficient mice. Antimicrob Agents Chemother, 34, 1629-32.
- Orme I.M., Roberts A.R. & Collins F.M. (1986) Lack of evidence for a reduction in the efficacy of subcutaneous BCG vaccination in mice infected with nontuberculous mycobacteria. Tubercle, 67, 41-6.